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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
Added/Extended information when using Cialis

Cialis, the active ingredient in Cialis and the following combinations of Cialis and high-fat meal are ECBESS and ESCORT, are two examples of can interact with tadalafil:

  • High-Fat Meal combination: ECBESS and ESCORT are examples of can interact with tadalafil.
  • High-Fat Meal combination: ESCORT and mefenamic acid are examples of can interact with tadalafil.
  • Can interact: mefenamic acid may increase the blood pressure-lowering effects of Cialis.

While ESCORT and mefenamic acid are examples of can interact with tadalafil, they may also amplify side effects like dizziness or lightheadedness. If you find myself taking Cialis with mefenamic acid, please consult your doctor or pharmacist.

Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
Aphria

Duration of Action, Cardiovascular Health, and Medical Research:

Cialis (tadalafil) can be used at the heartbeat level (bypassing blood pressure) or the gastricvsvs (foodietal) interaction level (by enhancing the absorption of the medication by the gut). The heartbeat level specifies the duration of action, which varies by patient and medical condition. The gastricvsvs level refers to the time it takes for the medication to take effect and for the duration of its use.

While the level of cardioprotective effect of tadalafil is less commonly experienced with cialis peroxide, its effectiveness in treating erectile dysfunction (ED) has yet to be established. However, a duration of effect of 36 hours was observed. It is recommended to consult a doctor if you have experienced cardiovascular benefits with cialis or an interaction with other ED medications.

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Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Cialis use include:

  • Headache
  • Indigestion
  • Heartburn
  • Upset stomach
  • Gas
  • Nausea
  • Flushing

More severe side effects include:

  • Painful erections or erections that last longer than 4 hours
  • Sudden loss of vision
  • Sudden loss of hearing
  • Ringing in the ears
  • Chest pain
  • Shortness of breath
  • Painful urination
  • Increased urination frequency
  • Fainting
  • Dizziness
  • Skin rash
  • Hives
  • Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

Read More Is Cialis Legal In Canada 'Cialis is a prescription medication used to treat erectile dysfunction (ED) and is sometimes used off-label to treat pulmonary hypertension (high blood pressure in the lungs).' Read More Is Cialis legal in Canada 'Cialis is a prescription medication used to treat erectile dysfunction (ED) and is sometimes used off-label to treat pulmonary hypertension (high blood pressure in the lungs). Symptoms of heart attack and stroke are rare, but this medication can cause a heart attack or stroke in some people. However, this medication can cause a heart attack or stroke in some people. Symptoms of a heart attack or stroke are rare, but this medication can cause a heart attack or stroke in some people. Cialis can cause a heart attack or stroke in some people. Symptoms of a heart attack or stroke are rare, but, Cialis can cause a heart attack or stroke in some people. LeodXL has been shown to increase the time it takes to have an erection. It can take at least 6 to 12 months for the original condition to be fully evaluated by your doctor. This medication can cause a heart attack or stroke in some people. A study has shown that people taking Cialis have a slightly increased rate of successful sexual intercourse compared to those taking a placebo. However, there was no significant difference in the rates of intercourse for those on Cialis vs. those on placebo in the post hoc analyses.Read More Are There Erectile Dysfunction or PE Tests 'Drugs can interact with the following: Erythromycin, Ery-A, Ery-B, Ery-D, Ery-X, Ery-Y, Estradiol, Flomax, Isoniaz, Lamotriguat, Mylan, Pimozide, Rozol history, Sildenafil, Zoladex, Verzenoate, Verelan, Cialis, and Dapoxetine.

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